Vacation Ideas?

So I have decided to go away on a solo vacation for Labor Day weekend. I've never really vacationed solo, and it is something I have always wanted to try.

Problem is, though, I have no idea where to go. I was thinking Rome. But it is quite scary to think about hitting a foreign country solo as a woman. Then I thought, "Maybe Canyon Ranch?" in western Mass. But I am kind of "spa-ed" out lately.

Ideas people? Anyone have any good places for a woman go to solo?

Thanks in advance for all suggestions!